D
IPR011626

Alpha-macroglobulin-like, TED domain

InterPro entry
Short nameAlpha-macroglobulin_TED
Overlapping
homologous
superfamilies
 
domain relationships

Description

This entry corresponds to the TED domain of the complement components such as C3, C4 and C5
[5]
. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved
[1, 4, 2, 3]
.

References

1.NMR solution structure of the receptor binding domain of human alpha(2)-macroglobulin. Huang W, Dolmer K, Liao X, Gettins PG. J. Biol. Chem. 275, 1089-94, (2000). View articlePMID: 10625650

2.Structure of complement receptor 2 in complex with its C3d ligand. Szakonyi G, Guthridge JM, Li D, Young K, Holers VM, Chen XS. Science 292, 1725-8, (2001). View articlePMID: 11387479

3.Structure at 1.44 A resolution of an N-terminally truncated form of the rat serum complement C3d fragment. Zanotti G, Bassetto A, Battistutta R, Folli C, Arcidiaco P, Stoppini M, Berni R. Biochim. Biophys. Acta 1478, 232-8, (2000). View articlePMID: 10825534

4.Structure of a rat alpha 1-macroglobulin receptor-binding domain dimer. Xiao T, DeCamp DL, Spran SR. Protein Sci. 9, 1889-97, (2000). View articlePMID: 11106161

5.Alpha-2-Macroglobulin in Inflammation, Immunity and Infections. Vandooren J, Itoh Y. Front Immunol 12, 803244, (2021). PMID: 34970276

GO terms

biological process

  • None

molecular function

  • None
Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.