F
IPR012373

Fe(2+)-dicitrate sensor, transmembrane component

InterPro entry
Short nameFerrdict_sens_TM

Description

This family contains transmembrane signal transduction proteins involved in Fe2+ dicitrate sensing. Experimentally characterised members include Escherichia coli FecR
[1]
and Pseudomonas putida PupR
[2]
. Members of this family are a distinct group of anti-sigma factors
[3]
.

In E. coli, binding of ferric citrate to the outer membrane receptor/transporter protein FecA initiates a signal that is transmitted by FecR across the cytoplasmic membrane into the cytoplasm where FecI, the sigma factor, is activated
[7]
. The periplasmic N terminus of FecA interacts with the periplasmic C-terminal portion of FecR, then FecR transmits the signal across the membrane, and the cytoplasmic N terminus of FecR interacts with FecI, which results in FecI activation
[4, 5, 6]
.

References

1.Novel two-component transmembrane transcription control: regulation of iron dicitrate transport in Escherichia coli K-12. Van Hove B, Staudenmaier H, Braun V. J. Bacteriol. 172, 6749-58, (1990). View articlePMID: 2254251

2.Role for the outer membrane ferric siderophore receptor PupB in signal transduction across the bacterial cell envelope. Koster M, van Klompenburg W, Bitter W, Leong J, Weisbeek P. EMBO J. 13, 2805-13, (1994). View articlePMID: 8026465

3.The anti-sigma factors. Hughes KT, Mathee K. Annu. Rev. Microbiol. 52, 231-86, (1998). View articlePMID: 9891799

4.Ferric citrate transport of Escherichia coli: functional regions of the FecR transmembrane regulatory protein. Welz D, Braun V. J. Bacteriol. 180, 2387-94, (1998). View articlePMID: 9573190

5.Surface signaling in ferric citrate transport gene induction: interaction of the FecA, FecR, and FecI regulatory proteins. Enz S, Mahren S, Stroeher UH, Braun V. J. Bacteriol. 182, 637-46, (2000). View articlePMID: 10633096

6.Detection of multiple extracytoplasmic function (ECF) sigma factors in the genome of Pseudomonas putida KT2440 and their counterparts in Pseudomonas aeruginosa PA01. Martinez-Bueno MA, Tobes R, Rey M, Ramos JL. Environ. Microbiol. 4, 842-55, (2002). View articlePMID: 12534467

7.Iron transport and signaling in Escherichia coli. Braun V, Braun M. FEBS Lett. 529, 78-85, (2002). View articlePMID: 12354617

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