IPR012671
Type III export protein PscE/YscE
InterPro entry
Short name | T3SS_PscE/YscE |
Description
Members of this family are found exclusively in type III secretion apparatus gene clusters in bacteria. Those bacteria with a protein from this family tend to target animal cells, as does Yersinia pestis
[3, 2, 1]. This is a small protein (about 70 amino acids) known as YscE in Y. pestis, SsaE of Salmonella spp., PscE of P. aeruginosa, AscE of A. hydrophila and EscE in Edwardsiella piscicida. They are described as the chaperones of the type III secretion (T3S) injectisome that translocates effector toxins into host cells, facilitating the establishment and dissemination of infection. EscE forms a complex with EsaH which interacts with EsaG, stabilizing it and therefore, controlling T3SS protein secretion as EsaG secretion itself leads to the secretion of the middle and late T3SS substrates
[4]. PscE prevents premature polymerization of PscF, along with PscG, within the cytoplasm
[5, 4], it is required for type III secretion needle assembly and also for cytotoxicity by influencing PscF levels.
References
1.Structural characterization of the Yersinia pestis type III secretion system needle protein YscF in complex with its heterodimeric chaperone YscE/YscG. Sun P, Tropea JE, Austin BP, Cherry S, Waugh DS. J. Mol. Biol. 377, 819-30, (2008). View articlePMID: 18281060
2.Crystal structure of the Yersinia type III secretion protein YscE. Phan J, Austin BP, Waugh DS. Protein Sci. 14, 2759-63, (2005). View articlePMID: 16195558
3.Analysis of virC, an operon involved in the secretion of Yop proteins by Yersinia enterocolitica. Michiels T, Vanooteghem JC, Lambert de Rouvroit C, China B, Gustin A, Boudry P, Cornelis GR. J. Bacteriol. 173, 4994-5009, (1991). View articlePMID: 1860816
Cross References
Genome Properties