D
IPR013118

Mannitol dehydrogenase, C-terminal

InterPro entry
Short nameMannitol_DH_C
Overlapping
homologous
superfamilies
 

Description

Long-chain mannitol dehydrogenases are a group of secondary alcohol dehydrogenases that differ from other alcohol or polyol dehydrogenases in that they do not utilise Zn(2+) or other metal cofactors and do not contain a conserved catalytic tyrosine residue. The proteins in this family that have been studied are monomeric enzymes of ~54kDa and include:
 * Mannitol-1-phosphate 5-dehydrogenase (
1.1.1.17
)
[1]

 * Mannitol 2-dehydrogenase (
1.1.1.67
)
[2]

 * D-arabinitol 4-dehydrogenase (
1.1.1.11
)
[3]

 * Altronate oxidoreductase (
1.1.1.58
)
 * D-mannonate oxidoreductase (
1.1.1.57
)

These enzymes are mostly found in bacteria, though they are also present in some fungal species.

References

1.Molecular analysis of the mannitol operon of Clostridium acetobutylicum encoding a phosphotransferase system and a putative PTS-modulated regulator. Behrens S, Mitchell W, Bahl H. Microbiology (Reading, Engl.) 147, 75-86, (2001). View articlePMID: 11160802

2.Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides. Schneider KH, Giffhorn F, Kaplan S. J. Gen. Microbiol. 139, 2475-84, (1993). PMID: 8254318

3.Genes for D-arabinitol and ribitol catabolism from Klebsiella pneumoniae. Heuel H, Shakeri-Garakani A, Turgut S, Lengeler JW. Microbiology (Reading, Engl.) 144 ( Pt 6), 1631-9, (1998). PMID: 9639934

Further reading

4. Crystal structure of Pseudomonas fluorescens mannitol 2-dehydrogenase binary and ternary complexes. Specificity and catalytic mechanism. Kavanagh KL, Klimacek M, Nidetzky B, Wilson DK. J. Biol. Chem. 277, 43433-42, (2002). View articlePMID: 12196534

GO terms

biological process

  • None

cellular component

  • None

Cross References

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