IPR013131
Mannitol dehydrogenase, N-terminal
InterPro entry
Short name | Mannitol_DH_N |
Overlapping homologous superfamilies |
Description
Mannitol-1-phosphate 5-dehydrogenase catalyses the NAD-dependent reduction of mannitol-1-phosphate to fructose-6-phosphate
[1] as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates
[2]. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose
[3]. Several dehydrogenases have been shown
[3] to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase (
1.1.1.17) (gene mtlD), mannitol 2-dehydrogenase (
1.1.1.67) (gene mtlK); mannonate oxidoreductase (
1.1.1.57) (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w. This domain has a Rossmann-type fold.
References
1.Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and comparison of the gene products with similar enzymes. Fischer R, von Strandmann RP, Hengstenberg W. J. Bacteriol. 173, 3709-15, (1991). View articlePMID: 1904856
2.Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system. Honeyman AL, Curtiss R 3rd. Infect. Immun. 60, 3369-75, (1992). View articlePMID: 1322373
GO terms
Cross References
ENZYME
Genome Properties
Contributing Member Database Entry
- Pfam:PF01232
Representative structure
5itg: Crystal structure of D-sorbitol dehydrogenase in substrate-free form