D
IPR013131

Mannitol dehydrogenase, N-terminal

InterPro entry
Short nameMannitol_DH_N
Overlapping
homologous
superfamilies
 

Description

Mannitol-1-phosphate 5-dehydrogenase catalyses the NAD-dependent reduction of mannitol-1-phosphate to fructose-6-phosphate
[1]
as part of the phosphoenolpyruvate-dependent phosphotransferase system (PTS). The PTS facilitates the vectorial translocation of metabolisable carbohydrates to form the corresponding sugar phosphates, which are then converted to glycolytic intermediates
[2]
. Mannitol 2-dehydrogenase catalyses the NAD-dependent reduction of mannitol to fructose
[3]
. Several dehydrogenases have been shown
[3]
to be evolutionary related, including mannitol-1-phosphate 5-dehydrogenase (
1.1.1.17
) (gene mtlD), mannitol 2-dehydrogenase (
1.1.1.67
) (gene mtlK); mannonate oxidoreductase (
1.1.1.57
) (fructuronate reductase) (gene uxuB); Escherichia coli hypothetical proteins ydfI and yeiQ; and yeast hypothetical protein YEL070w. This domain has a Rossmann-type fold.

References

1.Mannitol-specific phosphoenolpyruvate-dependent phosphotransferase system of Enterococcus faecalis: molecular cloning and nucleotide sequences of the enzyme IIIMtl gene and the mannitol-1-phosphate dehydrogenase gene, expression in Escherichia coli, and comparison of the gene products with similar enzymes. Fischer R, von Strandmann RP, Hengstenberg W. J. Bacteriol. 173, 3709-15, (1991). View articlePMID: 1904856

2.Isolation, characterization, and nucleotide sequence of the Streptococcus mutans mannitol-phosphate dehydrogenase gene and the mannitol-specific factor III gene of the phosphoenolpyruvate phosphotransferase system. Honeyman AL, Curtiss R 3rd. Infect. Immun. 60, 3369-75, (1992). View articlePMID: 1322373

3.Cloning, nucleotide sequence and characterization of the mannitol dehydrogenase gene from Rhodobacter sphaeroides. Schneider KH, Giffhorn F, Kaplan S. J. Gen. Microbiol. 139, 2475-84, (1993). PMID: 8254318

GO terms

biological process

  • None

cellular component

  • None

Cross References

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