IPR013815
ATP-grasp fold, subdomain 1
InterPro entry
Short name | ATP_grasp_subdomain_1 |
Overlapping entries |
Description
This entry represents subdomain 1 found at the N-terminal end of the ATP-grasp domain.
The ATP-grasp fold is one of several distinct ATP-binding folds, and is found in enzymes that catalyse the formation of amide bonds, catalysing the ATP-dependent ligation of a carboxylate-containing molecule to an amino or thiol group-containing molecule
[1]. This fold is found in many different enzyme families, including various peptide synthetases, biotin carboxylase, synapsin, succinyl-CoA synthetase, pyruvate phosphate dikinase, and glutathione synthetase, amongst others
[2]. These enzymes contribute predominantly to macromolecular synthesis, using ATP-hydrolysis to activate their substrates.
References
1.A diverse superfamily of enzymes with ATP-dependent carboxylate-amine/thiol ligase activity. Galperin MY, Koonin EV. Protein Sci. 6, 2639-43, (1997). View articlePMID: 9416615
2.Mutational analysis of ATP-grasp residues in the two ATP sites of Saccharomyces cerevisiae carbamoyl phosphate synthetase. Eroglu B, Powers-Lee SG. Arch. Biochem. Biophys. 407, 1-9, (2002). View articlePMID: 12392708
Further reading
3. A common fold for peptide synthetases cleaving ATP to ADP: glutathione synthetase and D-alanine:d-alanine ligase of Escherichia coli. Fan C, Moews PC, Shi Y, Walsh CT, Knox JR. Proc. Natl. Acad. Sci. U.S.A. 92, 1172-6, (1995). View articlePMID: 7862655
GO terms
Cross References
ENZYME
- 2.1.2.2
- 2.1.3.2
- 2.3.1.-
- 2.7.13.3
- 2.7.3.13
- 2.7.9.1
- 2.7.9.2
- 2.7.9.4
- 2.7.9.5
- 2.7.9.6
- 3.5.1.2
- 3.5.2.3
- 4.1.1.21
- 6.1.2.1
- 6.2.1.-
- 6.2.1.13
- 6.2.1.34
- 6.2.1.4
- 6.2.1.5
- 6.2.1.56
- 6.2.1.9
- 6.3.1.17
- 6.3.1.21
- 6.3.2.-
- 6.3.2.2
- 6.3.2.25
- 6.3.2.3
- 6.3.2.32
- 6.3.2.33
- 6.3.2.4
- 6.3.2.41
- 6.3.2.42
- 6.3.2.43
- 6.3.2.48
- 6.3.2.49
- 6.3.2.6
- 6.3.2.8
- 6.3.3.1
- 6.3.3.5
- 6.3.4.13
- 6.3.4.14
- 6.3.4.16
- 6.3.4.18
- 6.3.4.23
- 6.3.5.5
- 6.4.1.1
- 6.4.1.2
- 6.4.1.3
- 6.4.1.4
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:3.30.1490.20