F
IPR014376

Protein kinase C, delta/epsilon/eta/theta types

InterPro entry
Short nameProt_kin_PKC_delta
family relationships

Description

This entry represents the novel protein kinase C (nPKC) family.

The N-terminal regulatory domain of nPKC consists of a C2 domain follows by a double C1 domain (C1A and C1B). The C2 domain does not respond to calcium which makes nPKC diacylglycerol-sensitive but calcium-independent
[6, 5, 1]
.

PKC is a family of serine- and threonine-specific protein kinases that depend on lipids for activity. They can be activated by calcium but have a requirement for the second messenger diacylglycerol
[8, 7]
. Members of this family play key regulatory roles in various cellular processes. Currently, there are ten isoforms of PKC which can be classified into classical (alpha, beta I, beta II, gamma), novel (delta, epsilon, eta, theta) and atypical (zeta, iota/lambda) types based on their primary structure and biochemical characteristics
[3, 2, 4]
. All PKCs contain a C-terminal kinase domain and an N-terminal regulatory domain.

References

1.Protein kinase C isotypes and their specific functions: prologue. Ohno S, Nishizuka Y. J. Biochem. 132, 509-11, (2002). PMID: 12359062

2.Protein kinase C family: on the crossroads of cell signaling in skin and tumor epithelium. Breitkreutz D, Braiman-Wiksman L, Daum N, Denning MF, Tennenbaum T. J. Cancer Res. Clin. Oncol. 133, 793-808, (2007). View articlePMID: 17661083

3.The extended protein kinase C superfamily. Mellor H, Parker PJ. Biochem. J. 332 ( Pt 2), 281-92, (1998). PMID: 9601053

4.Signaling through protein kinase C. Toker A. Front. Biosci. 3, D1134-47, (1998). PMID: 9792904

5.Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C. Nishizuka Y. Science 258, 607-14, (1992). View articlePMID: 1411571

6.Lipid activation of protein kinases. Newton AC. J. Lipid Res. 50 Suppl, S266-71, (2009). View articlePMID: 19033211

7.Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. Kishimoto A, Takai Y, Mori T, Kikkawa U, Nishizuka Y. J. Biol. Chem. 255, 2273-6, (1980). PMID: 7358670

8.Studies on a cyclic nucleotide-independent protein kinase and its proenzyme in mammalian tissues. II. Proenzyme and its activation by calcium-dependent protease from rat brain. Inoue M, Kishimoto A, Takai Y, Nishizuka Y. J. Biol. Chem. 252, 7610-6, (1977). PMID: 199594

GO terms

Cross References

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