H
IPR014721

Small ribosomal subunit protein uS5 domain 2-type fold, subgroup

InterPro entry
Short nameRibsml_uS5_D2-typ_fold_subgr
Overlapping entries
 

Description

Domain 2 of the small ribosomal subunit protein uS5, previously known as ribosomal protein S5, has a left-handed β-α-β fold that is found in numerous RNA/DNA-binding proteins, as well as in kinases from the GHMP kinase family. Proteins containing this β-α-β fold domain include:


 * Translational machinery components (ribosomal proteins S5 and S9, and domain IV of elongation factors EF-G and eEF-2)
[1]
.
 * Ribonuclease P protein (RNase P)
[2]
.
 * DNA modification proteins (DNA mismatch repair proteins MutL and PMS2, DNA gyrase B, DNA topoisomerase II, IV-B and VI-B)
[3]
.
 * GHMP kinases that transfer a phosphoryl group from ATP to an acceptor (galactokinase (
2.7.1.6
), homoserine kinase (
2.7.1.39
), and mevalonate kinase (
2.7.1.36
))
[4, 5]
.
 * Caenorhabditis elegans early switch protein Xol-1 (a divergent member of the GHMP kinase family that has lost the ATP-binding site)
[6]
.

References

1.Structures of prokaryotic ribosomal proteins: implications for RNA binding and evolution. Ramakrishnan V, Davies C, Gerchman SE, Golden BL, Hoffmann DW, Jaishree TN, Kyila JH, Porter S, White SW. Biochem. Cell Biol. 73, 979-86, (1995). PMID: 8722013

2.Structure and function of eukaryotic Ribonuclease P RNA. Marquez SM, Chen JL, Evans D, Pace NR. Mol. Cell 24, 445-56, (2006). View articlePMID: 17081993

3.Structure and function of the N-terminal 40 kDa fragment of human PMS2: a monomeric GHL ATPase. Guarne A, Junop MS, Yang W. EMBO J. 20, 5521-31, (2001). View articlePMID: 11574484

4.Molecular functions of conserved aspects of the GHMP kinase family. Andreassi JL 2nd, Leyh TS. Biochemistry 43, 14594-601, (2004). View articlePMID: 15544330

5.Structure and mechanism of homoserine kinase: prototype for the GHMP kinase superfamily. Zhou T, Daugherty M, Grishin NV, Osterman AL, Zhang H. Structure 8, 1247-57, (2000). View articlePMID: 11188689

6.XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Luz JG, Hassig CA, Pickle C, Godzik A, Meyer BJ, Wilson IA. Genes Dev. 17, 977-90, (2003). View articlePMID: 12672694

Cross References

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