D
IPR015069

2H-phosphodiesterase-like, Domain of unknown function DUF1868

InterPro entry
Short name2H-PEstase_DUF1868
Overlapping
homologous
superfamilies
 

Description

This presumed domain is found in a group of 2H-phosphodiesterases predominantly from bacteria. Its presence in a large eukaryotic DNA virus represents a potential case of horizontal transfer from a bacterial source into a virus. Several proteins of bacterial origin have been noticed in the insect viruses and these appear to have been acquired from endo-symbiotic or parasitic bacteria that share the same host cells with the viruses. Presence of 2H proteins in the proteomes of large DNA viruses (e.g. T4 57B protein and the Fowl-pox virus FPV025) may point to some role for these proteins in regulating the viral tRNA metabolism
[1]
.

References

1.Detection of novel members, structure-function analysis and evolutionary classification of the 2H phosphoesterase superfamily. Mazumder R, Iyer LM, Vasudevan S, Aravind L. Nucleic Acids Res. 30, 5229-43, (2002). View articlePMID: 12466548

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