F
IPR015505

Coronin

InterPro entry
Short nameCoronin
Overlapping
homologous
superfamilies
 

Description

Coronins are evoluntionarily conserved WD-repeat-containing proteins mostly involved in actin cytoskeleton organisation. The WD40 motif is found in a multitude of eukaryotic proteins involved in a variety of cellular processes
[5]
. Repeated WD40 motifs act as a site for protein-protein interaction, and proteins containing WD40 repeats are known to serve as platforms for the assembly of protein complexes or mediators of transient interplay among other proteins. The final 40 amino acids are predicted to form a coiled-coil in a coronin homodimer
[3]
.

Coronin was first identified as an actin binding protein in Dictyostelium discoideum. It was named Coronin because of its association with crown-shaped cell surface projections of growth-phase D
[6]
. Since then, several Coronin homologues and isoforms have been identified from yeast to human. Mammalian Coronin isoforms include Coronin 1A/B/C, Coronin 2A/B, Coronin 6 and Coronin 7. The yeast Coronin homologue is known as Crn1, while the Drosophila homologue is known as pod1.

In budding yeast, Crn1 regulates the actin filament nucleation/branching activity of the actin-related protein 2/3 (Arp2/3) complex through interaction with the Arc35p subunit
[1]
.

Mammalian Coronin 1A is exclusively expressed in leukocytes and involved in the regulation of leukocyte specific signaling events
[4]
. The crystal structure of Coronin 1A has been solved
[7, 2]
. Mammalian Coronin 1B can protect new (ATP-rich) filaments from F-actin severing Cofilin and dismantle old (ADP-rich) filaments by inducing Arp2/3 dissociation in lamellipodia
[9, 8]
.

References

1.Direct regulation of Arp2/3 complex activity and function by the actin binding protein coronin. Humphries CL, Balcer HI, D'Agostino JL, Winsor B, Drubin DG, Barnes G, Andrews BJ, Goode BL. J. Cell Biol. 159, 993-1004, (2002). View articlePMID: 12499356

2.Coronin structure and implications. McArdle B, Hofmann A. Subcell. Biochem. 48, 56-71, (2008). PMID: 18925371

3.The coronin family of actin-associated proteins. de Hostos EL. Trends Cell Biol. 9, 345-50, (1999). View articlePMID: 10461187

4.Coronin 1 in innate immunity. Pieters J. Subcell. Biochem. 48, 116-23, (2008). PMID: 18925376

5.Pyrroloquinoline quinone (PQQ) and quinoprotein enzymes. Anthony C. Antioxid. Redox Signal. 3, 757-74, (2001). View articlePMID: 11761326

6.Coronin, an actin binding protein of Dictyostelium discoideum localized to cell surface projections, has sequence similarities to G protein beta subunits. de Hostos EL, Bradtke B, Lottspeich F, Guggenheim R, Gerisch G. EMBO J. 10, 4097-104, (1991). PMID: 1661669

7.The crystal structure of murine coronin-1: a regulator of actin cytoskeletal dynamics in lymphocytes. Appleton BA, Wu P, Wiesmann C. Structure 14, 87-96, (2006). View articlePMID: 16407068

8.Coronin 1B coordinates Arp2/3 complex and cofilin activities at the leading edge. Cai L, Marshall TW, Uetrecht AC, Schafer DA, Bear JE. Cell 128, 915-29, (2007). View articlePMID: 17350576

9.Coronin 1B antagonizes cortactin and remodels Arp2/3-containing actin branches in lamellipodia. Cai L, Makhov AM, Schafer DA, Bear JE. Cell 134, 828-42, (2008). View articlePMID: 18775315

Further reading

10. Role of Mammalian coronin 7 in the biosynthetic pathway. Rybakin V. Subcell. Biochem. 48, 110-5, (2008). PMID: 18925375

11. Coronin proteins as multifunctional regulators of the cytoskeleton and membrane trafficking. Rybakin V, Clemen CS. Bioessays 27, 625-32, (2005). View articlePMID: 15892111

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