F
IPR015507

Ribosomal RNA large subunit methyltransferase E

InterPro entry
Short namerRNA-MeTfrase_E
Overlapping
homologous
superfamilies
 
family relationships

Description

The ribosomal RNA large subunit methyltransferase E (
2.1.1
) methylates the 23S rRNA. It specifically methylates the uridine in position 2552 of 23s rRNA in the 50S particle using S-adenosyl-L-methionine as a substrate
[2]
. It was previously known as cell division protein FtsJ.

This entry represents the ribosomal RNA large subunit methyltransferase E family, which also includes tRNA (uridine-2'-O-)-methyltransferases. This enzyme methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop
[1]
.

References

1.Trm7p catalyses the formation of two 2'-O-methylriboses in yeast tRNA anticodon loop. Pintard L, Lecointe F, Bujnicki JM, Bonnerot C, Grosjean H, Lapeyre B. EMBO J. 21, 1811-20, (2002). View articlePMID: 11927565

2.The FtsJ/RrmJ heat shock protein of Escherichia coli is a 23 S ribosomal RNA methyltransferase. Caldas T, Binet E, Bouloc P, Costa A, Desgres J, Richarme G. J. Biol. Chem. 275, 16414-9, (2000). View articlePMID: 10748051

GO terms

cellular component

  • None

Cross References

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