D
IPR016073

SKP1 component, POZ domain

InterPro entry
Short nameSkp1_comp_POZ
Overlapping
homologous
superfamilies
 

Description

SKP1 (together with SKP2) was identified as an essential component of the cyclin A-CDK2 S phase kinase complex
[1]
. It was found to bind several F-box containing proteins (e.g., Cdc4, Skp2, cyclin F) and to be involved in the ubiquitin protein degradation pathway. A yeast homologue of SKP1 (P52286) was identified in the centromere bound kinetochore complex
[2]
and is also involved in the ubiquitin pathway
[3]
. In Dictyostelium discoideum (Slime mold) FP21 was shown to be glycosylated in the cytosol and has homology to SKP1
[4]
.

This entry represents a POZ domain with a core structure consisting of β(2)/α(2)/β(2)/α(2) in two layers, α/β. This domain is found at the N-terminal of SKP1 proteins
[5]
as well as in subunit D of the centromere DNA-binding protein complex Cbf3
[6]
.

References

1.Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function. Stebbins CE, Kaelin WG Jr, Pavletich NP. Science 284, 455-61, (1999). View articlePMID: 10205047

2.The Saccharomyces cerevisiae kinetochore contains a cyclin-CDK complexing homologue, as identified by in vitro reconstitution. Stemmann O, Lechner J. EMBO J. 15, 3611-20, (1996). View articlePMID: 8670864

3.Regulating the yeast kinetochore by ubiquitin-dependent degradation and Skp1p-mediated phosphorylation. Kaplan KB, Hyman AA, Sorger PK. Cell 91, 491-500, (1997). View articlePMID: 9390558

4.Characterization of FP21, a cytosolic glycoprotein from Dictyostelium. Kozarov E, van der Wel H, Field M, Gritzali M, Brown RD Jr, West CM. J. Biol. Chem. 270, 3022-30, (1995). View articlePMID: 7852383

5.Insights into SCF ubiquitin ligases from the structure of the Skp1-Skp2 complex. Schulman BA, Carrano AC, Jeffrey PD, Bowen Z, Kinnucan ER, Finnin MS, Elledge SJ, Harper JW, Pagano M, Pavletich NP. Nature 408, 381-6, (2000). View articlePMID: 11099048

6.Structural basis for phosphodependent substrate selection and orientation by the SCFCdc4 ubiquitin ligase. Orlicky S, Tang X, Willems A, Tyers M, Sicheri F. Cell 112, 243-56, (2003). View articlePMID: 12553912

GO terms

molecular function

  • None

cellular component

  • None

Cross References

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