D
IPR016201

PSI domain

InterPro entry
Short namePSI

Description

This domain is found in several different extracellular receptors, including plexins, which are involved in the development of neural and epithelial tissues
[1]
; in semaphorins, which regulate axon guidance, immune function and angiogenesis
[2]
; in integrins, which are important Metazoan adhesion receptors that transmit conformational change bidirectionally across the membrane (integrin alpha and beta subunits form a head and two long legs in the ectodomain and span the membrane)
[3]
; and in hepatocyte growth factor receptor, which plays important roles in normal development and in tumour growth and metastasis
[4]
.

References

1.Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility. Basile JR, Gavard J, Gutkind JS. J. Biol. Chem. 282, 34888-95, (2007). View articlePMID: 17855350

2.The ligand-binding face of the semaphorins revealed by the high-resolution crystal structure of SEMA4D. Love CA, Harlos K, Mavaddat N, Davis SJ, Stuart DI, Jones EY, Esnouf RM. Nat. Struct. Biol. 10, 843-8, (2003). View articlePMID: 12958590

3.Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Xiao T, Takagi J, Coller BS, Wang JH, Springer TA. Nature 432, 59-67, (2004). View articlePMID: 15378069

4.Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor. Stamos J, Lazarus RA, Yao X, Kirchhofer D, Wiesmann C. EMBO J. 23, 2325-35, (2004). View articlePMID: 15167892

Cross References

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