F
IPR016313

Disks large 1-like

InterPro entry
Short nameDLG1-like

Description

This entry represents the disks large 1 (DLG1) proteins, including DLG1 from flies and DLG1/2/3/4 from vertebrates. DLG1 is an essential multidomain scaffolding protein required for normal development
[2]
. It may play a role in adherens junction assembly, signal transduction, cell proliferation, synaptogenesis and lymphocyte activation
[3]
. Members of this group are involved in synaptic plasticity associated with NMDA receptor signalling
[1]

References

1.Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5. Brigidi GS, Santyr B, Shimell J, Jovellar B, Bamji SX. Nat Commun 6, 8200, (2015). PMID: 26334723

2.The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Woods DF, Bryant PJ. Cell 66, 451-64, (1991). View articlePMID: 1651169

3.The MAGUK protein MPP7 binds to the polarity protein hDlg1 and facilitates epithelial tight junction formation. Stucke VM, Timmerman E, Vandekerckhove J, Gevaert K, Hall A. Mol. Biol. Cell 18, 1744-55, (2007). View articlePMID: 17332497

GO terms

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.