IPR016689
ESCRT-2 complex, Snf8
InterPro entry
Short name | ESCRT-2_cplx_Snf8 |
Overlapping homologous superfamilies | |
family relationships |
Description
Snf8 (also known as Vps22p/Eap30) is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes.
The multivesicular body (MVB) protein-sorting pathway targets transmembrane proteins either for degradation or for function in the vacuole/lysosomes. The signal for entry into this pathway is monoubiquitination of protein cargo, which results in incorporation of cargo into luminal vesicles at late endosomes. Another crucial player is phosphatidylinositol 3-phosphate (PtdINS(3)P), which is enriched on early endosomes and on the luminal vesicles of MVBs. ESCRT (endosomal sorting complex required for transport)-I, -II and -III complexes are critical for MVB budding and sorting of monoubiquitinated cargo into the luminal vesicles
[1].
References
1.The emerging shape of the ESCRT machinery. Williams RL, Urbe S. Nat. Rev. Mol. Cell Biol. 8, 355-68, (2007). View articlePMID: 17450176
GO terms
biological process
molecular function
- None
cellular component
Contributing Member Database Entries
- PIRSF:PIRSF017215
- PANTHER:PTHR12806