F
IPR016689

ESCRT-2 complex, Snf8

InterPro entry
Short nameESCRT-2_cplx_Snf8
Overlapping
homologous
superfamilies
 
family relationships

Description

Snf8 (also known as Vps22p/Eap30) is a subunit of ESCRT-II, a protein complex involved in driving protein sorting from endosomes to lysosomes.

The multivesicular body (MVB) protein-sorting pathway targets transmembrane proteins either for degradation or for function in the vacuole/lysosomes. The signal for entry into this pathway is monoubiquitination of protein cargo, which results in incorporation of cargo into luminal vesicles at late endosomes. Another crucial player is phosphatidylinositol 3-phosphate (PtdINS(3)P), which is enriched on early endosomes and on the luminal vesicles of MVBs. ESCRT (endosomal sorting complex required for transport)-I, -II and -III complexes are critical for MVB budding and sorting of monoubiquitinated cargo into the luminal vesicles
[1]
.

References

1.The emerging shape of the ESCRT machinery. Williams RL, Urbe S. Nat. Rev. Mol. Cell Biol. 8, 355-68, (2007). View articlePMID: 17450176

GO terms

molecular function

  • None
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