D
IPR017456

CTP synthase, N-terminal

InterPro entry
Short nameCTP_synthase_N
Overlapping
homologous
superfamilies
 

Description

CTP synthase is involved in pyrimidine ribonucleotide/ribonucleoside metabolism, catalysing the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position
[1]
. The enzyme exists as a dimer which consists of an N-terminal synthetase domain and C-terminal glutaminase domain that aggregates as a tetramer. This gene has been found roughly 500 bp upstream of enolase in both beta (Nitrosomonas europaea) and gamma (Escherichia coli) subdivisions of Proteobacterium
[2]
.

This entry represents the N-terminal synthetase domain of CTP synthase.

References

1.Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme. Willemoes M. J. Biol. Chem. 278, 9407-11, (2003). View articlePMID: 12522217

2.Linkage of genes encoding enolase (eno) and CTP synthase (pyrG) in the beta-subdivision proteobacterium Nitrosomonas europaea. Mahony TJ, Miller DJ. FEMS Microbiol. Lett. 165, 153-7, (1998). PMID: 9711852

GO terms

Cross References

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