IPR017456
CTP synthase, N-terminal
InterPro entry
Short name | CTP_synthase_N |
Overlapping homologous superfamilies |
Description
CTP synthase is involved in pyrimidine ribonucleotide/ribonucleoside metabolism, catalysing the synthesis of CTP from UTP by amination of the pyrimidine ring at the 4-position
[1]. The enzyme exists as a dimer which consists of an N-terminal synthetase domain and C-terminal glutaminase domain that aggregates as a tetramer. This gene has been found roughly 500 bp upstream of enolase in both beta (Nitrosomonas europaea) and gamma (Escherichia coli) subdivisions of Proteobacterium
[2].
This entry represents the N-terminal synthetase domain of CTP synthase.
References
1.Thr-431 and Arg-433 are part of a conserved sequence motif of the glutamine amidotransferase domain of CTP synthases and are involved in GTP activation of the Lactococcus lactis enzyme. Willemoes M. J. Biol. Chem. 278, 9407-11, (2003). View articlePMID: 12522217
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME