EGF-like calcium-binding, conserved site
Short name | EGF_Ca-bd_CS |
Description
+------------------+ +---------+ | | | | nxnnC-x(3,14)-C-x(3,7)-CxxbxxxxaxC-x(1,6)-C-x(8,13)-Cx | | +------------------+ 'n': negatively charged or polar residue [DEQN] 'b': possibly beta-hydroxylated residue [DN] 'a': aromatic amino acid 'C': cysteine, involved in disulphide bond 'x': any amino acid.
References
1.The many faces of epidermal growth factor repeats. Davis CG. New Biol. 2, 410-9, (1990). PMID: 2288911
2.Vaccinia virus 19-kilodalton protein: relationship to several mammalian proteins, including two growth factors. Blomquist MC, Hunt LT, Barker WC. Proc. Natl. Acad. Sci. U.S.A. 81, 7363-7, (1984). View articlePMID: 6334307
3.[Similar domains in different proteins: detection and significance] Barker WC, Johnson GC, Hunt LT, George DG, Tsugita A. Tanpakushitsu Kakusan Koso 54-68, (1986). PMID: 3534958
4.Computer-based characterization of epidermal growth factor precursor. Doolittle RF, Feng DF, Johnson MS. Nature 307, 558-60, (1984). View articlePMID: 6607417
5.Structure and function of epidermal growth factor-like regions in proteins. Appella E, Weber IT, Blasi F. FEBS Lett. 231, 1-4, (1988). View articlePMID: 3282918
6.How an epidermal growth factor (EGF)-like domain binds calcium. High resolution NMR structure of the calcium form of the NH2-terminal EGF-like domain in coagulation factor X. Selander-Sunnerhagen M, Ullner M, Persson E, Teleman O, Stenflo J, Drakenberg T. J. Biol. Chem. 267, 19642-9, (1992). View articlePMID: 1527084
7.The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. Rao Z, Handford P, Mayhew M, Knott V, Brownlee GG, Stuart D. Cell 82, 131-41, (1995). View articlePMID: 7606779
GO terms
Cross References
Contributing Member Database Entry
- PROSITE patterns:PS01187