S
IPR018495

Succinate dehydrogenase, cytochrome b subunit, conserved site

InterPro entry
Short nameSucc_DH_cyt_bsu_CS

Description

Succinate dehydrogenase (SDH) is a membrane-bound complex of two main components: a membrane-extrinsic component composed of an FAD-binding flavoprotein and an iron-sulphur protein, and a hydrophobic component composed of a cytochrome b and a membrane anchor protein. The cytochrome b component is a mono-haem transmembrane protein
[2, 3, 4, 1]
belonging to a family that includes:


 * Cytochrome b-556 from bacterial SDH (gene sdhC).
 * Cytochrome b560 from the mammalian mitochondrial SDH complex, which is encoded in the mitochondrial genome of some algae and in the plant Marchantia polymorpha.
 * Cytochrome b from yeast mitochondrial SDH complex (gene SDH3 or CYB3).
 * Protein cyt-1 from Caenorhabditis elegans.


These cytochromes are proteins of about 130 residues that comprise three transmembrane regions. There are two conserved histidines which may be involved in binding the haem group.

References

1.Assembly of mitochondrial succinate dehydrogenase in human health and disease. Cao K, Xu J, Cao W, Wang X, Lv W, Zeng M, Zou X, Liu J, Feng Z. Free Radic Biol Med 207, 247-259, (2023). View articlePMID: 37490987

2.Cytochrome b560 (QPs1) of mitochondrial succinate-ubiquinone reductase. Immunochemistry, cloning, and nucleotide sequencing. Yu L, Wei YY, Usui S, Yu CA. J. Biol. Chem. 267, 24508-15, (1992). View articlePMID: 1447196

3.Characterization of the Saccharomyces cerevisiae nuclear gene CYB3 encoding a cytochrome b polypeptide of respiratory complex II. Abraham PR, Mulder A, van 't Riet J, Raue HA. Mol. Gen. Genet. 242, 708-16, (1994). View articlePMID: 8152421

4.Complete sequence of the mitochondrial DNA of the rhodophyte Chondrus crispus (Gigartinales). Gene content and genome organization. Leblanc C, Boyen C, Richard O, Bonnard G, Grienenberger JM, Kloareg B. J. Mol. Biol. 250, 484-95, (1995). View articlePMID: 7616569

GO terms

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.