IPR019815
Translation initiation factor 3, C-terminal
InterPro entry
Short name | Translation_initiation_fac_3_C |
Overlapping homologous superfamilies |
Description
Initiation factor 3 (IF-3) (gene infC) is one of the three factors required for the initiation of protein biosynthesis in bacteria. IF-3 is thought to function as a fidelity factor during the assembly of the ternary initiation complex which consist of the 30S ribosomal subunit, the initiator tRNA and the messenger RNA. IF-3 is a basic protein that binds to the 30S ribosomal subunit
[1]. The chloroplast initiation factor IF-3(chl) is a protein that enhances the poly(A,U,G)-dependent binding of the initiator tRNA to chloroplast ribosomal 30s subunits in which the central section is evolutionary related to the sequence of bacterial IF-3
[2].
References
1.Molecular cloning and sequencing of infC, the gene encoding translation initiation factor IF3, from four enterobacterial species. Liveris D, Schwartz JJ, Geertman R, Schwartz I. FEMS Microbiol. Lett. 112, 211-6, (1993). View articlePMID: 8405963
2.Isolation and characterization of cDNA clones for chloroplast translational initiation factor-3 from Euglena gracilis. Lin Q, Ma L, Burkhart W, Spremulli LL. J. Biol. Chem. 269, 9436-44, (1994). View articlePMID: 8144528
GO terms
Contributing Member Database Entry
- Pfam:PF00707
Representative structure
1tig: TRANSLATION INITIATION FACTOR 3 C-TERMINAL DOMAIN