F
IPR020461

High affinity nerve growth factor receptor NTRK1

InterPro entry
Short nameNTRK1
family relationships

Description

Neurotrophins are a family of secreted proteins that regulate development, maintenance and function of vertebrate nervous systems. They act via two different classes of receptor: p75NTR (a member of the TNF receptor superfamily), and neurotrophic tyrosine kinase receptors (NTRKs) - also known as tropomyosin-related kinases (Trks)
[1]
.

NTRK1 (also termed TrkA) is a high-affinity receptor for nerve growth factor (NGF). The receptor is expressed in the dorsal root ganglia, trigeminal ganglia and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons
[2]
. It is also expressed in peripheral sites, such as scalp skin
[3]
. Whereas p75NTR activation by NGF induces apoptosis, NTRK1 mediates the growth factor's cell survival-promoting effects
[4]
.

References

1.Functional interactions of neurotrophins and neurotrophin receptors. Bothwell M. Annu. Rev. Neurosci. 18, 223-53, (1995). View articlePMID: 7605062

2.Transcriptional regulation of Trk family neurotrophin receptors. Lei L, Parada LF. Cell. Mol. Life Sci. 64, 522-32, (2007). View articlePMID: 17192812

3.Expression of nerve growth factor and its high-affinity receptor, tyrosine kinase A proteins, in the human scalp skin. Adly MA, Assaf HA, Nada EA, Soliman M, Hussein M. J. Cutan. Pathol. 33, 559-68, (2006). View articlePMID: 16919030

4.Competitive signaling between TrkA and p75 nerve growth factor receptors determines cell survival. Yoon SO, Casaccia-Bonnefil P, Carter B, Chao MV. J. Neurosci. 18, 3273-81, (1998). PMID: 9547236

Further reading

5. Neurotrophins: roles in neuronal development and function. Huang EJ, Reichardt LF. Annu. Rev. Neurosci. 24, 677-736, (2001). View articlePMID: 11520916

GO terms

Cross References

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