D
IPR021870

Major vault protein, shoulder domain

InterPro entry
Short nameMVP_shoulder
Overlapping
homologous
superfamilies
 

Description

The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Several roles for vaults have been proposed. Vault proteins have been associated with development of multi-drug resistance
[1]
. They have also being implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses
[3]
.

This domain is found in the Major Vault Protein and has been called the shoulder domain
[2]
. This family includes two bacterial proteins
A6FXE2
and
A1ZGE7
. This suggests that some bacteria may possess vault particles.

References

1.The role of major vault protein (MVP) in drug resistance. Park K. J Control Release 163, 266, (2012). View articlePMID: 23083532

2.The structure of rat liver vault at 3.5 angstrom resolution. Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T. Science 323, 384-8, (2009). View articlePMID: 19150846

3.Vaults and the major vault protein: novel roles in signal pathway regulation and immunity. Berger W, Steiner E, Grusch M, Elbling L, Micksche M. Cell. Mol. Life Sci. 66, 43-61, (2009). View articlePMID: 18759128

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