IPR021870
Major vault protein, shoulder domain
InterPro entry
Short name | MVP_shoulder |
Overlapping homologous superfamilies |
Description
The major vault protein is the major polypeptide component of a large cellular ribonuclear protein complex found in the cytoplasm of eukaryotic cells. Several roles for vaults have been proposed. Vault proteins have been associated with development of multi-drug resistance
[1]. They have also being implicated in the regulation of several cellular processes including transport mechanisms, signal transmission and immune responses
[3].
References
1.The role of major vault protein (MVP) in drug resistance. Park K. J Control Release 163, 266, (2012). View articlePMID: 23083532
2.The structure of rat liver vault at 3.5 angstrom resolution. Tanaka H, Kato K, Yamashita E, Sumizawa T, Zhou Y, Yao M, Iwasaki K, Yoshimura M, Tsukihara T. Science 323, 384-8, (2009). View articlePMID: 19150846
3.Vaults and the major vault protein: novel roles in signal pathway regulation and immunity. Berger W, Steiner E, Grusch M, Elbling L, Micksche M. Cell. Mol. Life Sci. 66, 43-61, (2009). View articlePMID: 18759128