F
IPR022495

Serine/threonine-protein kinase Bud32

InterPro entry
Short nameBud32
Overlapping
homologous
superfamilies
 

Description

Serine/threonine-protein kinase Bud32 is conserved from Archaea to human. In many Archaeal genomes, Kae1 and Bud32 are fused
[1]
. The complex is homologous to the Kae1 and Bud32 subunits of the eukaryotic KEOPS complex (composed of Bud32, Kae1, Cgi121, Pcc1 and Gon7), an apparently ancient protein kinase-containing molecular machine that is essential for t6A tRNA modification
[2, 3, 4]
.

References

1.Structure of the archaeal Kae1/Bud32 fusion protein MJ1130: a model for the eukaryotic EKC/KEOPS subcomplex. Hecker A, Lopreiato R, Graille M, Collinet B, Forterre P, Libri D, van Tilbeurgh H. EMBO J. 27, 2340-51, (2008). View articlePMID: 19172740

2.The universal Kae1 protein and the associated Bud32 kinase (PRPK), a mysterious protein couple probably essential for genome maintenance in Archaea and Eukarya. Hecker A, Graille M, Madec E, Gadelle D, Le Cam E, van Tilbergh H, Forterre P. Biochem. Soc. Trans. 37, 29-35, (2009). View articlePMID: 19143597

3.The highly conserved KEOPS/EKC complex is essential for a universal tRNA modification, t6A. Srinivasan M, Mehta P, Yu Y, Prugar E, Koonin EV, Karzai AW, Sternglanz R. EMBO J. 30, 873-81, (2011). View articlePMID: 21183954

4.The structural and functional workings of KEOPS. Beenstock J, Sicheri F. Nucleic Acids Res 49, 10818-10834, (2021). PMID: 34614169

GO terms

biological process

  • None

cellular component

  • None

Cross References

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