F
IPR024874

Transcription factor Maf family

InterPro entry
Short nameTranscription_factor_Maf_fam

Description

Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors
[1]
. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.

References

1.Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes. Kataoka K. J. Biochem. 141, 775-81, (2007). View articlePMID: 17569705

GO terms

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