IPR024874
Transcription factor Maf family
InterPro entry
Short name | Transcription_factor_Maf_fam |
Description
Maf transcription factors form a distinct subfamily of the basic leucine zipper (bZip) transcription factors
[1]. Maf genes have been identified in a wide range of higher eukaryotes, including both vertebrate and invertebrate species. These proteins are unique among the bZip factors in that they contain a highly conserved extended homology region (EHR), or ancillary DNA binding region, in addition to a typical basic region, and both regions are involved in target DNA sequence recognition. Maf transcription factors regulate tissue-specific gene expression and cell-differentiation in a wide variety of tissues and are also involved in human diseases and oncogenic transformation. Tissue-specific expression invloves Maf binding to Maf-recognition elements (MAREs) in the regulatory regions of target genes, and interacting with other transcription factors.
References
1.Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes. Kataoka K. J. Biochem. 141, 775-81, (2007). View articlePMID: 17569705
GO terms
biological process
molecular function
cellular component
- None
Contributing Member Database Entry
- PANTHER:PTHR10129