S
IPR025527

HUWE1/REV1, ubiquitin-binding motif

InterPro entry
Short nameHUWE1/Rev1_UBM

Description

This entry contains repetitive elements (RE) from a subgroup of HECT E3 ubiquitin ligases and the Y-family translesion polymerases, including human HUWE1 and REV1. Each of these repetitive elements are approximately 20 amino acids in length and contain two predicted helical segments separated by a Leu-Pro motif. The REs from the Y-family polymerases were shown to bind ubiquitin and were the basis for a novel ubiquitin-binding domain called the ubiquitin-binding motif (UBM)
[3, 1, 2]
.

References

1.Structures of REV1 UBM2 Domain Complex with Ubiquitin and with a Small-Molecule that Inhibits the REV1 UBM2-Ubiquitin Interaction. Vanarotti M, Grace CR, Miller DJ, Actis ML, Inoue A, Evison BJ, Vaithiyalingam S, Singh AP, McDonald ET, Fujii N. J Mol Biol 430, 2857-2872, (2018). PMID: 29864443

2.Solenoid architecture of HUWE1 contributes to ligase activity and substrate recognition. Hunkeler M, Jin CY, Ma MW, Monda JK, Overwijn D, Bennett EJ, Fischer ES. Mol Cell 81, 3468-3480.e7, (2021). PMID: 34314700

3.The UVS9 gene of Chlamydomonas encodes an XPG homolog with a new conserved domain. Deitsch E, Hibbard EM, Petersen JL. DNA Repair (Amst.) 37, 33-42, (2016). View articlePMID: 26658142

Cross References

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