IPR025929
Insulin-induced protein family
InterPro entry
Short name | INSIG_fam |
Description
This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations
[2, 1].
References
1.Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Yabe D, Brown MS, Goldstein JL. Proc. Natl. Acad. Sci. U.S.A. 99, 12753-8, (2002). View articlePMID: 12242332
2.Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS. Cell 110, 489-500, (2002). View articlePMID: 12202038
3.INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY. EMBO J. 24, 3917-26, (2005). View articlePMID: 16270032