F
IPR025929

Insulin-induced protein family

InterPro entry
Short nameINSIG_fam

Description

This family contains a number of eukaryotic Insulin-induced proteins (INSIG-1 and INSIG-2) approximately 200 residues long. INSIG-1 and INSIG-2 are found in the endoplasmic reticulum and bind the sterol-sensing domain of SREBP cleavage-activating protein (SCAP), preventing it from escorting SREBPs to the Golgi. Their combined action permits feedback regulation of cholesterol synthesis over a wide range of sterol concentrations
[2, 1]
.

The INSIG family also includes NSG1 and NSG2 (INSIG homologues 1 and 2)
[3]
.

References

1.Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Yabe D, Brown MS, Goldstein JL. Proc. Natl. Acad. Sci. U.S.A. 99, 12753-8, (2002). View articlePMID: 12242332

2.Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. Yang T, Espenshade PJ, Wright ME, Yabe D, Gong Y, Aebersold R, Goldstein JL, Brown MS. Cell 110, 489-500, (2002). View articlePMID: 12202038

3.INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY. EMBO J. 24, 3917-26, (2005). View articlePMID: 16270032

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