D
IPR025995

RNA binding activity-knot of a chromodomain

InterPro entry
Short nameTudor-knot
Overlapping
homologous
superfamilies
 
domain relationships

Description

This is a novel knotted tudor domain which is required for binding to RNA. The knot influences the loop conformation of the helical turn Ht2 (residues 61-63) that is located at the side opposite the knot in the tudor domain-chromo domain; stabilisation of Ht2 is essential for RNA binding
[1]
.

References

1.Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. Shimojo H, Sano N, Moriwaki Y, Okuda M, Horikoshi M, Nishimura Y. J. Mol. Biol. 378, 987-1001, (2008). View articlePMID: 18407291

Cross References

Contributing Member Database Entry
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