IPR025995
RNA binding activity-knot of a chromodomain
InterPro entry
Short name | Tudor-knot |
Overlapping homologous superfamilies | |
domain relationships |
Description
This is a novel knotted tudor domain which is required for binding to RNA. The knot influences the loop conformation of the helical turn Ht2 (residues 61-63) that is located at the side opposite the knot in the tudor domain-chromo domain; stabilisation of Ht2 is essential for RNA binding
[1].
References
1.Novel structural and functional mode of a knot essential for RNA binding activity of the Esa1 presumed chromodomain. Shimojo H, Sano N, Moriwaki Y, Okuda M, Horikoshi M, Nishimura Y. J. Mol. Biol. 378, 987-1001, (2008). View articlePMID: 18407291
Cross References
Contributing Member Database Entry
- Pfam:PF11717
Representative structure
6bph: Crystal structure of the chromodomain of RBBP1