D
IPR026890

Mononegavirales mRNA-capping domain V

InterPro entry
Short nameMononeg_mRNAcap

Description

L protein (large polymerase protein) is a polymerase protein. The V domain of L RNA-polymerase carries a new motif, GxxTx(n)HR, that is essential for mRNA cap formation. Nonsegmented negative-sense (NNS) RNA viruses, Mononegavirales, cap their mRNA by an unconventional mechanism. Specifically, 5'-monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate between the large polymerase protein L and mRNA. The V region is essential for this process
[1]
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References

1.A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping. Li J, Rahmeh A, Morelli M, Whelan SP. J. Virol. 82, 775-84, (2008). View articlePMID: 18003731

Cross References

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