IPR026890
Mononegavirales mRNA-capping domain V
InterPro entry
Short name | Mononeg_mRNAcap |
Description
L protein (large polymerase protein) is a polymerase protein. The V domain of L RNA-polymerase carries a new motif, GxxTx(n)HR, that is essential for mRNA cap formation. Nonsegmented negative-sense (NNS) RNA viruses, Mononegavirales, cap their mRNA by an unconventional mechanism. Specifically, 5'-monophosphate mRNA is transferred to GDP derived from GTP through a reaction that involves a covalent intermediate between the large polymerase protein L and mRNA. The V region is essential for this process
[1].
References
1.A conserved motif in region v of the large polymerase proteins of nonsegmented negative-sense RNA viruses that is essential for mRNA capping. Li J, Rahmeh A, Morelli M, Whelan SP. J. Virol. 82, 775-84, (2008). View articlePMID: 18003731
Cross References
Contributing Member Database Entry
- Pfam:PF14318