IPR027483
Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
InterPro entry
Short name | PInositol-4-P-4/5-kinase_C_sf |
Overlapping entries |
Description
This superfamily represents the C-terminal domain of the phosphatidylinositol-4-phosphate 4/5-kinases (PIP4K/PIP5K). It has a 2-layer sandwich structure
[1]. PIP4/5K catalyses the formation of phosphoinositol-4,5-bisphosphate via the phosphorylation of phosphatidylinositol-4-phosphate a precursor in the phosphoinositide signalling pathway
[2].
References
1.Structure of type IIbeta phosphatidylinositol phosphate kinase: a protein kinase fold flattened for interfacial phosphorylation. Rao VD, Misra S, Boronenkov IV, Anderson RA, Hurley JH. Cell 94, 829-39, (1998). View articlePMID: 9753329
2.Type I phosphatidylinositol-4-phosphate 5-kinases. Cloning of the third isoform and deletion/substitution analysis of members of this novel lipid kinase family. Ishihara H, Shibasaki Y, Kizuki N, Wada T, Yazaki Y, Asano T, Oka Y. J. Biol. Chem. 273, 8741-8, (1998). View articlePMID: 9535851
Cross References
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:3.30.810.10
Representative structure
6ym4: Crystal structure of BAY-297 with PIP4K2A