F
IPR027492

Dual-specificity RNA methyltransferase RlmN

InterPro entry
Short nameRNA_MTrfase_RlmN
Overlapping
homologous
superfamilies
 
family relationships

Description

Dual-specificity RNA methyltransferase RlmN specifically methylates position 2 of adenine 2503 in 23S rRNA, which serves to optimize ribosomal fidelity, and position 2 of adenine 37 in tRNAs. Unmodified tRNA is not a suitable substrate for RlmN, which suggests that RlmN works in a late step during tRNA maturation
[1, 2, 3]
.

References

1.The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA. Toh SM, Xiong L, Bae T, Mankin AS. RNA 14, 98-106, (2008). View articlePMID: 18025251

2.A radically different mechanism for S-adenosylmethionine-dependent methyltransferases. Grove TL, Benner JS, Radle MI, Ahlum JH, Landgraf BJ, Krebs C, Booker SJ. Science 332, 604-7, (2011). View articlePMID: 21415317

3.The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy. Benitez-Paez A, Villarroya M, Armengod ME. RNA 18, 1783-95, (2012). View articlePMID: 22891362

GO terms

molecular function

  • None

cellular component

  • None

Cross References

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