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IPR027882

SOGA 1/2-like, coiled-coil

InterPro entry
Short nameSOGA1/2-like_CC

Description

This entry represents a coiled-coil region found in microtubule cross-linking factors 1 and 2 (also known as SOGA1/2), which are members of the SOGA (suppressor of glucose by autophagy) family. SOGA1 regulates autophagy by playing a role in the reduction of glucose production in an adiponectin-and insulin-dependent manner
[2]
. It is required for faithful chromosome segregation during mitosis
[1]
. This entry also includes KIAA0408, an uncharacterised human protein.

References

1.SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells. Ferreira LT, Logarinho E, Macedo JC, Maia ARR, Maiato H. Chromosome Res 29, 159-173, (2021). View articlePMID: 33587225

2.Adiponectin lowers glucose production by increasing SOGA. Cowherd RB, Cowerd RB, Asmar MM, Alderman JM, Alderman EA, Garland AL, Busby WH, Bodnar WM, Rusyn I, Medoff BD, Tisch R, Mayer-Davis E, Swenberg JA, Zeisel SH, Combs TP. Am. J. Pathol. 177, 1936-45, (2010). View articlePMID: 20813965

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