IPR028215
Refilin family
InterPro entry
Short name | Refilin |
Description
This protein family includes the actin regulators, Refilin A and B. Refilin (also known as Cfm or FAM101) is thought to stabilise peri-nuclear actin filament bundles, important in fibroblasts. Refilin is important as changes in localisation and shape in the nucleus plays a role in cellular and developmental processes
[1]. Refilins are essential partner molecules of Filamin B involved in regulating differentiation and proliferation of chondryocytes
[2].
References
1.RefilinB (FAM101B) targets filamin A to organize perinuclear actin networks and regulates nuclear shape. Gay O, Gilquin B, Nakamura F, Jenkins ZA, McCartney R, Krakow D, Deshiere A, Assard N, Hartwig JH, Robertson SP, Baudier J. Proc. Natl. Acad. Sci. U.S.A. 108, 11464-9, (2011). View articlePMID: 21709252
2.Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements. Mizuhashi K, Kanamoto T, Moriishi T, Muranishi Y, Miyazaki T, Terada K, Omori Y, Ito M, Komori T, Furukawa T. Hum. Mol. Genet. 23, 2953-67, (2014). View articlePMID: 24436304
GO terms
biological process
molecular function
cellular component
- None