H
IPR029048

Heat shock protein 70kD, C-terminal domain superfamily

InterPro entry
Short nameHSP70_C_sf
Overlapping entries
 

Description

Members of the 70-kilodalton heat-shock protein (HSP70) family promote protein folding both constitutively and in response to stress. These proteins have two functional units: a substrate-binding unit, and an adenosine triphosphatase unit. The substrate-binding unit of DnaK consists of a β-sandwich domain followed by α-helical segments. The α-helical domain stabilises the complex, but does not contact the peptide directly
[1]
.

This superfamily represents the C-terminal α-helical subdomain of the substrate-binding unit from DnaK and other HSP70 proteins.

References

1.Structural analysis of substrate binding by the molecular chaperone DnaK. Zhu X, Zhao X, Burkholder WF, Gragerov A, Ogata CM, Gottesman ME, Hendrickson WA. Science 272, 1606-14, (1996). View articlePMID: 8658133

Cross References

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