F
IPR030050

Taste receptor type 2 member 38

InterPro entry
Short nameTAS2R38
family relationships

Description

Taste receptor type 2 member 38 (TAS2R38), a member of the G-protein-coupled bitter receptor family, is the bitter taste receptor responsible for the ability to taste phenylthiocarbamide (PTC)
[1, 3]
. This protein also has a crucial role in neutrophil-mediated host immunity against Pseudomonas aeruginosa infection in mice
[2]
.

References

1.Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D. Science 299, 1221-5, (2003). View articlePMID: 12595690

2.Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection. Pu Q, Guo K, Lin P, Wang Z, Qin S, Gao P, Combs C, Khan N, Xia Z, Wu M. Signal Transduct Target Ther 6, 210, (2021). PMID: 34083514

3.A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. Prandi S, Bromke M, Hubner S, Voigt A, Boehm U, Meyerhof W, Behrens M. PLoS One 8, e82820, (2013). PMID: 24367558

GO terms

Contributing Member Database Entry
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