S
IPR030492

Rel homology domain, conserved site

InterPro entry
Short nameRHD_CS

Description

Members of the Rel family share a highly conserved 300 amino acids domain termed Rel homology domain (RHD) which is located towards the amino terminus. The unique C terminus is thought to be involved in gene activation and cytoplasmic anchoring functions.

For several proteins it has been demonstrated
[1]
that the Rel homology domain includes:

     * a DNA-binding domain, which binds to the consensus DNA sequence motif 5'-GGGRNNYYCC-3' (except for dorsal, which recognises the related motif 5'-GRGAAAANCC-3');
     * a dimerisation domain, which is located in the C-terminal part of the RHD;
     * a PKA phosphorylation site (except in RelB);
     * a nuclear localization signal (NLS), which consists of a stretch of four or five basic residues.

This entry represents a conserved site located at the N terminus of the RHD. It includes a conserved cysteine that seems to be essential for DNA-binding in p50
[2]
.

References

1.The Rel family of proteins in oncogenesis and differentiation. Kabrun N, Enrietto PJ. Semin. Cancer Biol. 5, 103-12, (1994). PMID: 8061327

2.Two different cellular redox systems regulate the DNA-binding activity of the p50 subunit of NF-kappa B in vitro. Mitomo K, Nakayama K, Fujimoto K, Sun X, Seki S, Yamamoto K. Gene 145, 197-203, (1994). View articlePMID: 8056331

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