IPR031176
ELL/occludin family
InterPro entry
Short name | ELL/occludin |
family relationships |
Description
This entry represents the ELL/occludin family. Occludin is found in the tight junction and may play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier
[1]. ELL is a family of RNA polymerase II elongation factors. It is bound stably to elongation-associated factors 1 and 2, EAFs, and together these act as a strong regulator of transcription activity by direct interaction with Pol II. ELL binds to pol II on its own but the affinity is greatly increased by the cooperation of EAF
[2].
References
1.PKC eta regulates occludin phosphorylation and epithelial tight junction integrity. Suzuki T, Elias BC, Seth A, Shen L, Turner JR, Giorgianni F, Desiderio D, Guntaka R, Rao R. Proc. Natl. Acad. Sci. U.S.A. 106, 61-6, (2009). View articlePMID: 19114660
2.Identification and Characterization of a Schizosaccharomyces pombe RNA Polymerase II Elongation Factor with Similarity to the Metazoan Transcription Factor ELL. Banks CA, Kong SE, Spahr H, Florens L, Martin-Brown S, Washburn MP, Conaway JW, Mushegian A, Conaway RC. J. Biol. Chem. 282, 5761-9, (2007). View articlePMID: 17150956
Contributing Member Database Entry
- PANTHER:PTHR23288
Representative structure
1wpa: 1.5 Angstrom crystal structure of human occludin fragment 413-522