S
IPR031303

DNA methylase, C-5 cytosine-specific, conserved site

InterPro entry
Short nameC5_meth_CS

Description

C-5 cytosine-specific DNA methylases (C5 Mtase) are enzymes that specifically methylate the C-5 carbon of cytosines in DNA
[1, 3, 2]
. Such enzymes are found in the proteins described below.


 * As a component of type II restriction-modification systems in prokaryotes and some bacteriophages. Such enzymes recognise a specific DNA sequence where they methylate a cytosine. In doing so, they protect DNA from cleavage by type II restriction enzymes that recognise the same sequence. The sequences of a large number of type II C-5 Mtases are known.
 * In vertebrates, there are a number of C-5 Mtases that methylate CpG dinucleotides. The sequence of the mammalian enzyme is known.


C-5 Mtases share a number of short conserved regions. This conserved region is located at the C-terminal extremity in type-II enzymes.

References

1.Sequence motifs specific for cytosine methyltransferases. Posfai J, Bhagwat AS, Roberts RJ. Gene 74, 261-5, (1988). View articlePMID: 3248729

2.Cytosine-specific type II DNA methyltransferases. A conserved enzyme core with variable target-recognizing domains. Lauster R, Trautner TA, Noyer-Weidner M. J. Mol. Biol. 206, 305-12, (1989). View articlePMID: 2716049

3.The DNA (cytosine-5) methyltransferases. Kumar S, Cheng X, Klimasauskas S, Mi S, Posfai J, Roberts RJ, Wilson GG. Nucleic Acids Res. 22, 1-10, (1994). View articlePMID: 8127644

Cross References

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