IPR034004
Pol I subunit A12, C-terminal zinc ribbon
InterPro entry
Short name | Zn_ribbon_RPA12_C |
domain relationships |
Description
The C-terminal zinc ribbon domain of subunit A12 in RNA polymerase (Pol) I (RPA12) is involved in intrinsic transcript cleavage
[2, 1]. Eukaryote genomes are transcribed by three nuclear RNA polymerases (Pol I, II and III) that share some subunits. RPA12 in Pol I, RPB9 in Pol II, RPC11 in Pol III and TFS in archaea are distantly related to each other and to the TFIIS elongation factor of Pol II
[2]. RPA12 has two zinc-binding domains separated by a flexible linker
[3].
References
1.Evolution of two modes of intrinsic RNA polymerase transcript cleavage. Ruan W, Lehmann E, Thomm M, Kostrewa D, Cramer P. J. Biol. Chem. 286, 18701-7, (2011). View articlePMID: 21454497
2.Transcriptional termination by RNA polymerase I requires the small subunit Rpa12p. Prescott EM, Osheim YN, Jones HS, Alen CM, Roan JG, Reeder RH, Beyer AL, Proudfoot NJ. Proc. Natl. Acad. Sci. U.S.A. 101, 6068-73, (2004). View articlePMID: 15073335
3.Rpa12p, a conserved RNA polymerase I subunit with two functional domains. Van Mullem V, Landrieux E, Vandenhaute J, Thuriaux P. Mol. Microbiol. 43, 1105-13, (2002). View articlePMID: 11918799
Contributing Member Database Entry
- CDD:cd10507