F
IPR035106

Spastin, chordate

InterPro entry
Short nameSpastin_chordate
family relationships

Description

Spastin is an ATP-dependent microtubule severing protein. Microtubule severing may promote reorganisation of cellular microtubule arrays and the release of microtubules from the microtubule organising centre following nucleation
[2, 1, 3]
.

This entry represents Spastin specific to chordates.

References

1.The identification of a conserved domain in both spartin and spastin, mutated in hereditary spastic paraplegia. Ciccarelli FD, Proukakis C, Patel H, Cross H, Azam S, Patton MA, Bork P, Crosby AH. Genomics 81, 437-41, (2003). View articlePMID: 12676568

2.Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics. Errico A, Ballabio A, Rugarli EI. Hum. Mol. Genet. 11, 153-63, (2002). View articlePMID: 11809724

3.Linking axonal degeneration to microtubule remodeling by Spastin-mediated microtubule severing. Evans KJ, Gomes ER, Reisenweber SM, Gundersen GG, Lauring BP. J. Cell Biol. 168, 599-606, (2005). View articlePMID: 15716377

Further reading

4. Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Hazan J, Fonknechten N, Mavel D, Paternotte C, Samson D, Artiguenave F, Davoine CS, Cruaud C, Durr A, Wincker P, Brottier P, Cattolico L, Barbe V, Burgunder JM, Prud'homme JF, Brice A, Fontaine B, Heilig B, Weissenbach J. Nat. Genet. 23, 296-303, (1999). View articlePMID: 10610178

GO terms

biological process

  • None

cellular component

  • None

Cross References

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