H
IPR036277

SMCs flexible hinge superfamily

InterPro entry
Short nameSMC_hinge_sf
Overlapping entries
 

Description

This entry represents the hinge region superfamily of the SMC (Structural Maintenance of Chromosomes) family of proteins. The hinge region is responsible for formation of the DNA interacting dimer. It is also possible that its precise structure is an essential determinant of the specificity of the DNA-protein interaction
[1]
.

The structure of this hinge region consists of two different α+β subdomains and forms subdomain-swapped dimers.

References

1.Hinge-mediated dimerization of SMC protein is essential for its dynamic interaction with DNA. Hirano M, Hirano T. EMBO J. 21, 5733-44, (2002). View articlePMID: 12411491

GO terms

Cross References

Contributing Member Database Entry
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