LexA/Signal peptidase-like superfamily
Short name | LexA/Signal_pep-like_sf |
Overlapping entries |
Description
* the lambda repressor CI/C2 family and related bacterial prophage repressor proteins
* LexA, the diverse family of bacterial transcription factors that repress genes in the cellular SOS response to DNA damage
* MucA and the related UmuD proteins, which are lesion-bypass DNA polymerases, induced in response to mitogenic DNA damage
* RulA, a component of the rulAB locus that confers resistance to UV.
References
1.The UmuD' protein filament and its potential role in damage induced mutagenesis. Peat TS, Frank EG, McDonald JP, Levine AS, Woodgate R, Hendrickson WA. Structure 4, 1401-12, (1996). View articlePMID: 8994967
2.Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor. Paetzel M, Dalbey RE, Strynadka NC. Nature 396, 186-90, (1998). View articlePMID: 9823901
3.Analysis of Escherichia coli RecA interactions with LexA, lambda CI, and UmuD by site-directed mutagenesis of recA. Mustard JA, Little JW. J. Bacteriol. 182, 1659-70, (2000). View articlePMID: 10692372
4.Converting a DNA damage checkpoint effector (UmuD2C) into a lesion bypass polymerase (UmuD'2C). Ferentz AE, Walker GC, Wagner G. EMBO J. 20, 4287-98, (2001). View articlePMID: 11483531
5.Crystal structure of LexA: a conformational switch for regulation of self-cleavage. Luo Y, Pfuetzner RA, Mosimann S, Paetzel M, Frey EA, Cherney M, Kim B, Little JW, Strynadka NC. Cell 106, 585-94, (2001). View articlePMID: 11551506
6.Crystal structure of the lambda repressor C-terminal domain provides a model for cooperative operator binding. Bell CE, Frescura P, Hochschild A, Lewis M. Cell 101, 801-11, (2000). View articlePMID: 10892750
7.Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity. McDonald JP, Peat TS, Levine AS, Woodgate R. J. Mol. Biol. 285, 2199-209, (1999). View articlePMID: 9925794
8.Plasmid-encoded MucB protein is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA, and SSB. Goldsmith M, Sarov-Blat L, Livneh Z. Proc. Natl. Acad. Sci. U.S.A. 97, 11227-31, (2000). View articlePMID: 11016960
9.Genetic and biochemical characterization of a novel umuD mutation: insights into a mechanism for UmuD self-cleavage. Sutton MD, Kim M, Walker GC. J. Bacteriol. 183, 347-57, (2001). View articlePMID: 11114935
Cross References
Contributing Member Database Entry
- SUPERFAMILY:SSF51306