H
IPR036437

Outer surface protein C-like superfamily

InterPro entry
Short nameOspC-like_sf
Overlapping entries
 

Description

Members of this superfamily are lipoproteins that are probably involved in evasion of the host immune system by pathogens
[4]
. Borrelia burgdorferi, the causative agent of Lyme disease, has the potential of producing more than 100 different lipoproteins that could become anchored to the outer membrane
[2]
. One of these is outer surface protein C (OspC). OspC is a largely α-helical protein that forms a dimer with a characteristic central four-helical bundle formed by association of the two longest helices from each subunit
[3, 1]
.

References

1.Crystal structure of Lyme disease antigen outer surface protein C from Borrelia burgdorferi. Eicken C, Sharma V, Klabunde T, Owens RT, Pikas DS, Hook M, Sacchettini JC. J. Biol. Chem. 276, 10010-5, (2001). View articlePMID: 11139584

2.A bacterial genome in flux: the twelve linear and nine circular extrachromosomal DNAs in an infectious isolate of the Lyme disease spirochete Borrelia burgdorferi. Casjens S, Palmer N, van Vugt R, Huang WM, Stevenson B, Rosa P, Lathigra R, Sutton G, Peterson J, Dodson RJ, Haft D, Hickey E, Gwinn M, White O, Fraser CM. Mol. Microbiol. 35, 490-516, (2000). View articlePMID: 10672174

3.Crystal structure of outer surface protein C (OspC) from the Lyme disease spirochete, Borrelia burgdorferi. Kumaran D, Eswaramoorthy S, Luft BJ, Koide S, Dunn JJ, Lawson CL, Swaminathan S. EMBO J. 20, 971-8, (2001). View articlePMID: 11230121

4.Genomic sequence of a Lyme disease spirochaete, Borrelia burgdorferi. Fraser CM, Casjens S, Huang WM, Sutton GG, Clayton R, Lathigra R, White O, Ketchum KA, Dodson R, Hickey EK, Gwinn M, Dougherty B, Tomb JF, Fleischmann RD, Richardson D, Peterson J, Kerlavage AR, Quackenbush J, Salzberg S, Hanson M, van Vugt R, Palmer N, Adams MD, Gocayne J, Weidman J, Utterback T, Watthey L, McDonald L, Artiach P, Bowman C, Garland S, Fuji C, Cotton MD, Horst K, Roberts K, Hatch B, Smith HO, Venter JC. Nature 390, 580-6, (1997). View articlePMID: 9403685

GO terms

biological process

  • None

molecular function

  • None
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