Glutamyl tRNA-reductase dimerization domain superfamily
Short name | GluRdtase_dimer_dom_sf |
Overlapping entries |
Description
* The first stage in tetrapyrrole synthesis is the synthesis of 5-aminoaevulinic acid ALA via two possible routes: (1) condensation of succinyl CoA and glycine (C4 pathway) using ALA synthase (
* The second stage is to convert ALA to uroporphyrinogen III, the first macrocyclic tetrapyrrolic structure in the pathway. This is achieved by the action of three enzymes in one common pathway: porphobilinogen (PBG) synthase (or ALA dehydratase,
* Uroporphyrinogen III is the first branch point of the pathway. To synthesise cobalamin (vitamin B12), sirohaem, and coenzyme F430, uroporphyrinogen III needs to be converted into precorrin-2 by the action of uroporphyrinogen III methyltransferase (
References
1.V-shaped structure of glutamyl-tRNA reductase, the first enzyme of tRNA-dependent tetrapyrrole biosynthesis. Moser J, Schubert WD, Beier V, Bringemeier I, Jahn D, Heinz DW. EMBO J. 20, 6583-90, (2001). View articlePMID: 11726494
2.Evolutionary relationship between initial enzymes of tetrapyrrole biosynthesis. Schulze JO, Schubert WD, Moser J, Jahn D, Heinz DW. J. Mol. Biol. 358, 1212-20, (2006). View articlePMID: 16564539
3.Tetrapyrrole biosynthesis in higher plants. Tanaka R, Tanaka A. 58, 321-46, (2007). View articlePMID: 17227226
4.Biosynthesis of cobalamin (vitamin B12): a bacterial conundrum. Raux E, Schubert HL, Warren MJ. Cell. Mol. Life Sci. 57, 1880-93, (2000). View articlePMID: 11215515
5.Glutamyl-transfer RNA: a precursor of heme and chlorophyll biosynthesis. Jahn D, Verkamp E, Soll D. Trends Biochem. Sci. 17, 215-8, (1992). View articlePMID: 1502723
GO terms
biological process
molecular function
cellular component
- None
Cross References
ENZYME
Contributing Member Database Entry
- SUPERFAMILY:SSF69075