H
IPR036737

OmpA-like domain superfamily

InterPro entry
Short nameOmpA-like_sf
Overlapping entries
 
OmpA-like domain (IPR006665)

Description

This entry represents a domain superfamily with a β/α/β/α-β(2) structure found in the C-terminal region of many Gram-negative bacterial outer membrane proteins
[1]
, such as porin-like integral membrane proteins (such as ompA)
[9]
, small lipid-anchored proteins (such as pal)
[4]
, and MotB proton channels
[8]
. The N-terminal half is variable although some of the proteins in this group have the OmpA-like transmembrane domain
IPR000498
at the N terminus. OmpA from Escherichia coli is required for pathogenesis, and can interact with host receptor molecules
[7]
. MotB (and MotA) serves two functions in E. coli, the MotA(4)-MotB(2) complex attaches to the cell wall via MotB to form the stator of the flagellar motor, and the MotA-MotB complex couples the flow of ions across the cell membrane to movement of the rotor
[8]
.

Other Gram-negative outer membrane proteins with this domain:


 * Outer membrane protein P5 from Haemophilus influenzae.
 * Outer membrane protein P.III/class IV from Neisseria.
 * Outer membrane porin F (gene oprF) from Pseudomonas.
 * Protein TpN50 from Treponema pallidum
[5]
.
 * Peptidoglycan-associated lipoprotein (gene pal) from Escherichia coli, Haemophilus influenzae, Legionella pneumophila and Pseudomonas putida.
 * Outer membrane lipoprotein P6 from Haemophilus influenzae.
 * Escherichia coli hypothetical lipoprotein yiaD.
 * Vibrio parahaemolyticus sodium-type flagellar protein motY
[3, 2]
.


The OmpA-like domain is thought to be responsible for non-covalent interactions with peptidoglycan
[6]
.

References

1.Homology of the root adhesin of Pseudomonas fluorescens OE 28.3 with porin F of P. aeruginosa and P. syringae. De Mot R, Proost P, Van Damme J, Vanderleyden J. Mol. Gen. Genet. 231, 489-93, (1992). View articlePMID: 1538702

2.Interactions of MotX with MotY and with the PomA/PomB sodium ion channel complex of the Vibrio alginolyticus polar flagellum. Okabe M, Yakushi T, Homma M. J. Biol. Chem. 280, 25659-64, (2005). View articlePMID: 15866878

3.Cloning and characterization of motY, a gene coding for a component of the sodium-driven flagellar motor in Vibrio alginolyticus. Okunishi I, Kawagishi I, Homma M. J. Bacteriol. 178, 2409-15, (1996). PMID: 8636046

4.In vitro characterization of peptidoglycan-associated lipoprotein (PAL)-peptidoglycan and PAL-TolB interactions. Bouveret E, Benedetti H, Rigal A, Loret E, Lazdunski C. J. Bacteriol. 181, 6306-11, (1999). View articlePMID: 10515919

5.Identification and characterization of the Treponema pallidum tpn50 gene, an ompA homolog. Hardham JM, Stamm LV. Infect. Immun. 62, 1015-25, (1994). View articlePMID: 8112835

6.Structure of the OmpA-like domain of RmpM from Neisseria meningitidis. Grizot S, Buchanan SK. Mol. Microbiol. 51, 1027-37, (2004). View articlePMID: 14763978

7.Outer membrane protein A of Escherichia coli K1 selectively enhances the expression of intercellular adhesion molecule-1 in brain microvascular endothelial cells. Selvaraj SK, Periandythevar P, Prasadarao NV. Microbes Infect. 9, 547-57, (2007). View articlePMID: 17368067

8.The Escherichia coli MotAB proton channel unplugged. Hosking ER, Vogt C, Bakker EP, Manson MD. J. Mol. Biol. 364, 921-37, (2006). View articlePMID: 17052729

9.Export and sorting of the Escherichia coli outer membrane protein OmpA. Freudl R, Klose M, Henning U. J. Bioenerg. Biomembr. 22, 441-9, (1990). View articlePMID: 2202726

Cross References

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