H
IPR036890

Histidine kinase/HSP90-like ATPase superfamily

InterPro entry
Short nameHATPase_C_sf
Overlapping entries
 

Description

This domain superfamily is found in several ATP-binding proteins, including: histidine kinase
[5]
, DNA gyrase B, topoisomerases
[1]
, heat shock protein HSP90
[2, 3, 4]
, phytochrome-like ATPases and DNA mismatch repair proteins. The fold of this domain consists of two layers, α/β, which contains an 8-stranded mixed β-sheet.

References

1.Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase. Bellon S, Parsons JD, Wei Y, Hayakawa K, Swenson LL, Charifson PS, Lippke JA, Aldape R, Gross CH. Antimicrob. Agents Chemother. 48, 1856-64, (2004). View articlePMID: 15105144

2.Ligand-induced conformational shift in the N-terminal domain of GRP94, an Hsp90 chaperone. Immormino RM, Dollins DE, Shaffer PL, Soldano KL, Walker MA, Gewirth DT. J. Biol. Chem. 279, 46162-71, (2004). View articlePMID: 15292259

3.The Mechanism of Hsp90 regulation by the protein kinase-specific cochaperone p50(cdc37). Roe SM, Ali MM, Meyer P, Vaughan CK, Panaretou B, Piper PW, Prodromou C, Pearl LH. Cell 116, 87-98, (2004). View articlePMID: 14718169

4.Structure-activity relationships in purine-based inhibitor binding to HSP90 isoforms. Wright L, Barril X, Dymock B, Sheridan L, Surgenor A, Beswick M, Drysdale M, Collier A, Massey A, Davies N, Fink A, Fromont C, Aherne W, Boxall K, Sharp S, Workman P, Hubbard RE. Chem. Biol. 11, 775-85, (2004). View articlePMID: 15217611

5.Crystal structure of the C-terminal domain of the two-component system transmitter protein nitrogen regulator II (NRII; NtrB), regulator of nitrogen assimilation in Escherichia coli. Song Y, Peisach D, Pioszak AA, Xu Z, Ninfa AJ. Biochemistry 43, 6670-8, (2004). View articlePMID: 15157101

Cross References

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