H
IPR036956

Impact, N-terminal domain superfamily

InterPro entry
Short nameImpact_N_sf
Overlapping entries
 
Impact, N-terminal (IPR001498)
Impact YigZ-like (IPR015796)
Impact family (IPR023582)

Description

The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea
[1]
.

This entry represents the N-terminal domain superfamily of the Impact proteins.

References

1.Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. Okamura K, Hagiwara-Takeuchi Y, Li T, Vu TH, Hirai M, Hattori M, Sakaki Y, Hoffman AR, Ito T. Genome Res. 10, 1878-89, (2000). View articlePMID: 11116084

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