IPR036956
Impact, N-terminal domain superfamily
InterPro entry
Short name | Impact_N_sf |
Overlapping entries |
Description
The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea
[1].
This entry represents the N-terminal domain superfamily of the Impact proteins.
References
1.Comparative genome analysis of the mouse imprinted gene impact and its nonimprinted human homolog IMPACT: toward the structural basis for species-specific imprinting. Okamura K, Hagiwara-Takeuchi Y, Li T, Vu TH, Hirai M, Hattori M, Sakaki Y, Hoffman AR, Ito T. Genome Res. 10, 1878-89, (2000). View articlePMID: 11116084
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:3.30.230.30
Representative structure
2cve: Crystal structure of a conserved hypothetical protein TT1547 from thermus thermophilus HB8