D
IPR037601

ANKS4B, SAM domain

InterPro entry
Short nameANKS4B_SAM
Overlapping
homologous
superfamilies
 
domain relationships

Description

ANKS4B (also known as Harp) is part of the intermicrovillar adhesion complex (IMAC) and plays a role in epithelial brush border differentiation, controlling microvilli organization and length. It interacts with USH1C and MYO7B, which link protocadherins to the actin cytoskeleton
[2]
. In mouse epithelial tissues, HARP interacts with the PDZ domain of harmonin. This scaffolding complex facilitates signal transduction in epithelia
[1]
.

References

1.Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues. Johnston AM, Naselli G, Niwa H, Brodnicki T, Harrison LC, Gonez LJ. Genes Cells 9, 967-82, (2004). View articlePMID: 15461667

2.ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Crawley SW, Weck ML, Grega-Larson NE, Shifrin DA Jr, Tyska MJ. Dev. Cell 36, 190-200, (2016). View articlePMID: 26812018

GO terms

molecular function

  • None

cellular component

  • None
Contributing Member Database Entry
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