IPR037601
ANKS4B, SAM domain
InterPro entry
Short name | ANKS4B_SAM |
Overlapping homologous superfamilies | |
domain relationships |
Description
ANKS4B (also known as Harp) is part of the intermicrovillar adhesion complex (IMAC) and plays a role in epithelial brush border differentiation, controlling microvilli organization and length. It interacts with USH1C and MYO7B, which link protocadherins to the actin cytoskeleton
[2]. In mouse epithelial tissues, HARP interacts with the PDZ domain of harmonin. This scaffolding complex facilitates signal transduction in epithelia
[1].
References
1.Harp (harmonin-interacting, ankyrin repeat-containing protein), a novel protein that interacts with harmonin in epithelial tissues. Johnston AM, Naselli G, Niwa H, Brodnicki T, Harrison LC, Gonez LJ. Genes Cells 9, 967-82, (2004). View articlePMID: 15461667
2.ANKS4B Is Essential for Intermicrovillar Adhesion Complex Formation. Crawley SW, Weck ML, Grega-Larson NE, Shifrin DA Jr, Tyska MJ. Dev. Cell 36, 190-200, (2016). View articlePMID: 26812018
GO terms
Contributing Member Database Entry
- CDD:cd09587