D
IPR037671

GPI ethanolamine phosphate transferase 1, N-terminal

InterPro entry
Short namePIGN_N
Overlapping
homologous
superfamilies
 

Description

GPI ethanolamine phosphate transferase 1 (also known as PIGN) is an ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation
[1]
.

This entry represents the N-terminal domain of PIGN.

References

1.Replication stress links structural and numerical cancer chromosomal instability. Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. Nature 494, 492-496, (2013). View articlePMID: 23446422

GO terms

Contributing Member Database Entry
This website requires cookies, and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our Privacy Notice and Terms of Use.