IPR037671
GPI ethanolamine phosphate transferase 1, N-terminal
InterPro entry
Short name | PIGN_N |
Overlapping homologous superfamilies |
Description
GPI ethanolamine phosphate transferase 1 (also known as PIGN) is an ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. It catalyzes the transfer of ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. It may act as suppressor of replication stress and chromosome missegregation
[1].
This entry represents the N-terminal domain of PIGN.
References
1.Replication stress links structural and numerical cancer chromosomal instability. Burrell RA, McClelland SE, Endesfelder D, Groth P, Weller MC, Shaikh N, Domingo E, Kanu N, Dewhurst SM, Gronroos E, Chew SK, Rowan AJ, Schenk A, Sheffer M, Howell M, Kschischo M, Behrens A, Helleday T, Bartek J, Tomlinson IP, Swanton C. Nature 494, 492-496, (2013). View articlePMID: 23446422
GO terms
biological process
molecular function
cellular component
Contributing Member Database Entry
- CDD:cd16020