D
IPR037767

Mug190-like, C2A domain

InterPro entry
Short nameC2A_Mug190-like
Overlapping
homologous
superfamilies
 
domain relationships

Description

Meiotically up-regulated gene 190 protein (Mug190) from Schizosaccharomyces pombe derives its name from a study to identify genes essential for meiosis
[3]
. It is thought to correspond to tricalbin 2 in Saccharomyces cerevisiae. Tricalbins are C2 domain proteins involved in ER-plasma membrane tethering
[1]
.

C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements: type I and type II, distinguished by a circular permutation involving their N- and C-terminal β strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This entry represents the first C2 repeat of Mug190, C2A, and has a type-II topology
[2]
.

References

1.ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology. Manford AG, Stefan CJ, Yuan HL, Macgurn JA, Emr SD. Dev. Cell 23, 1129-40, (2012). View articlePMID: 23237950

2.The tricalbin C2 domains: lipid-binding properties of a novel, synaptotagmin-like yeast protein family. Schulz TA, Creutz CE. Biochemistry 43, 3987-95, (2004). View articlePMID: 15049706

3.A large-scale screen in S. pombe identifies seven novel genes required for critical meiotic events. Martin-Castellanos C, Blanco M, Rozalen AE, Perez-Hidalgo L, Garcia AI, Conde F, Mata J, Ellermeier C, Davis L, San-Segundo P, Smith GR, Moreno S. Curr. Biol. 15, 2056-62, (2005). View articlePMID: 16303567

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