IPR038597
GGGP/HepGP synthase superfamily
InterPro entry
Short name | GGGP/HepGP_synthase_sf |
Overlapping entries |
Description
This entry represents geranylgeranylglyceryl phosphate (GGGP) synthase and Heptaprenylglyceryl phosphate (HepGP) synthase.
GGGP synthase is a prenyltransferase that catalyses the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. This entry also matches putative glycerol-1-phosphate prenyltransferases that may catalyse the transfer of a prenyl moiety to sn-glycerol-1-phosphate (G1P)
[1].
References
1.Identification and characterization of a bacterial glycerol-1-phosphate dehydrogenase: Ni(2+)-dependent AraM from Bacillus subtilis. Guldan H, Sterner R, Babinger P. Biochemistry 47, 7376-84, (2008). View articlePMID: 18558723
Further reading
2. Functional Assignment of an Enzyme that Catalyzes the Synthesis of an Archaea-Type Ether Lipid in Bacteria. Guldan H, Matysik FM, Bocola M, Sterner R, Babinger P. Angew. Chem. Int. Ed. Engl. (2011). PMID: 21761520
Cross References
ENZYME
Contributing Member Database Entry
- CATH-Gene3D:G3DSA:3.20.20.390
Representative structure
4jej: GGGPS from Flavobacterium johnsoniae