F
IPR039424

Solute-binding protein family 5

InterPro entry
Short nameSBP_5
family relationships

Description

Bacterial high affinity transport systems are involved in active transport of solutes across the cytoplasmic membrane. Most of the bacterial ABC (ATP-binding cassette) importers are composed of one or two transmembrane permease proteins, one or two nucleotide-binding proteins and a highly specific periplasmic solute-binding protein. In Gram-negative bacteria the solute-binding proteins are dissolved in the periplasm, while in archaea and Gram-positive bacteria, their solute-binding proteins are membrane-anchored lipoproteins
[1, 3]
.

On the basis of sequence similarities, the vast majority of these solute-binding proteins can be grouped
[2]
into eight families or clusters, which generally correlate with the nature of the solute bound.

References

1.Sequence relationships between integral inner membrane proteins of binding protein-dependent transport systems: evolution by recurrent gene duplications. Saurin W, Dassa E. Protein Sci. 3, 325-44, (1994). View articlePMID: 8003968

2.Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Tam R, Saier MH Jr. Microbiol. Rev. 57, 320-46, (1993). View articlePMID: 8336670

3.Characterization of a Pseudomonas putida ABC transporter (AatJMQP) required for acidic amino acid uptake: biochemical properties and regulation by the Aau two-component system. Singh B, Rohm KH. Microbiology (Reading, Engl.) 154, 797-809, (2008). View articlePMID: 18310026

Further reading

4. The novel transcription factor SgrR coordinates the response to glucose-phosphate stress. Vanderpool CK, Gottesman S. J. Bacteriol. 189, 2238-48, (2007). View articlePMID: 17209026

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